Cytogenetic Studies of Recurrent Miscarriage- A Review
Yamini Pokale *
Department of Biotechnology, Shri Jagdishprasad Jhabarmal Tibrewal University, Jhunjhunu, Rajasthan, India
Prashant Khadke
Department of Biotechnology, Shri Jagdishprasad Jhabarmal Tibrewal University, Jhunjhunu, Rajasthan, India
*Author to whom correspondence should be addressed.
Abstract
Recurrent miscarriage occurs in 1–3% of couples aiming at childbirth. It continues to be a challenging reproductive problem for the patient and clinician. Therefore, identifying a cytogenetic cause for a miscarriage may be of great significance for the management of recurrent miscarriage patients. Genetic factors in the form of chromosomal abnormalities, inherited Thrombophilia, single gene disorders and other genes involved are the main causes of recurrent miscarriage. The risk of miscarriage is highest among couples where the woman’s age is 35 years or above and men’s age is more than 40 years. Constitutional chromosomal abnormalities with great risk to be transmitted to offspring are rare, but their discovery is of crucial importance in prevention of spontaneous abortion and recurrent miscarriage.
Keywords: Recurrent miscarriage, chromosomal abnormality, cytogenetics